- Noninvasive mathematical analysis of spectral electrocardiographic components for coronary lesions of intermediate to obstructive stenosis severity–relationship with classic and functional SYNTAX score
Catheterization Cardiovascular Interventions, Volume 86, Issue 1, July 2015, Pages 21–29
http://onlinelibrary.wiley.com/doi/10.1002/ccd.25924/full - The Diagnostic Performance of Multifunction Cardiogram (MCG) in Functional Myocardial Ischemia
Annals of Noninvasive Electrocardiology / Volume 20, Issue 5, pages 508–510, September 2015
http://onlinelibrary.wiley.com/wol1/doi/10.1111/anec.12299/full - TCTAP A-086 Comparison of a Two-Lead, Computerized, Resting ECG Signal Analysis Device, the Multifunction-CardioGram (MCG), to Coronary Angiography or MDCT, SPECT for the Detection of Revalent Coronary Artery Stenosis
J Am Coll Cardiol. 2015;65(17_S):S45-S45. doi:10.1016/j.jacc.2015.03.148
http://content.onlinejacc.org/article.aspx?articleid=2281099 - Non-invasive assessment of functionally significant coronary stenoses through mathematical analysis of spectral ECG components
Open Heart 2014;1: doi:10.1136/openhrt-2014-000144
http://www.premierheart.com/webapp/downloads/Articles/OpenHeart_20141201.pdf - A Paired-Comparision of the MultiFunction CardioGrams (MCG) and SPECT Myocardial Perfusion Imaging (MPI)
International Journal of Medical Sciences 2011;8(8):717-72
http://www.premierheart.com/webapp/downloads/Articles/IJMS_2011_8.pdf - Comparing MCG and Coronary Angiography for detection of Coronary Artery Stenosis in Women
Treatment Strategies – Cardiology Volume 3, Issue 1 pp.82-91
http://www.premierheart.com/webapp/downloads/Articles/TreatmentStrategies_3.1_82.pdf
Appropriateness Guidelines for the use of MCG in clinical settings are currently being revised in conjunction with the American College of Computational Electrophysiology. New guidelines will be posted shortly. - A Meta-Analysis of the MCG clinical trials
International Journal of Medical Sciences April 2009 6(4):143-155
http://www.premierheart.com/webapp/downloads/Articles/IJMS_2009_04.pdf - An analysis of the Asian Multi-Center Trial
Congestive Heart Failure 2008 14: 251-260
http://www.premierheart.com/webapp/downloads/clinical_trials/Asia-2004.pdf - An analysis of the Siegburg clinical trial (post-revascularization)
International Journal of Medical Sciences 2008 5(2): 50-61
http://www.premierheart.com/webapp/downloads/clinical_trials/Siegburg-2003-revasc.pdf - An analysis of the Siegburg clinical trial (no revascularization)
International Journal of Medical Sciences 2007 4(5): 249-263
http://www.premierheart.com/webapp/downloads/clinical_trials/Siegburg-2003-norevasc.pdf - An analysis of the Westchester clinical trial
Heart Disease 2002 4: 2-12
http://www.premierheart.com/webapp/downloads/clinical_trials/Westchester-2000.pdf - Peer-Reviewed Abstracts and Presentations
An analysis of the effect of age, gender and revascularization on MCG results
(Based upon the Siegburg studies) Circulation 2007 116: II_367
Abstract | Presentation Slides - A comparison of the MCG system to coronary angiography
American College of Chest Physicians October 2007 132(4): 466S
Abstract | Presentation Slides
(Based upon the Post-Revascularization Siegburg study) - Invited Talks
American College of Cardiology 2011
Dr. John Strobeck presented a poster session comparing the accuracy of MCG to Myocardial Perfusion Imaging (MPI / Nuclear Stress Imaging).
Presentation Handout - American Academy of Urgent Care Medicine
Drs. Imhoff, Strobeck and Shen discuss the MCG system, including trial results, practical clinical examples and the underlying technology.
A presentation before the Academy’s 2008 annual meeting
Presentation Video
The following peer-reviewed studies do not include a focus on the MCG, but provide large-scale clinical evidence for the need of appropriate, accurate technology for risk-stratifying patients who present with chest pain and heart disease symptoms to the hospital ER.
- Cardiac Imaging Tests Beget More Tests, but No Benefit. Michael O’Riordan, Medscape, February 10, 2014. Link: https://www.medscape.com/viewarticle/820401 .
- Low Diagnostic Yield of Elective Coronary Angiography. Manesh R. Patel, M.D., Eric D. Peterson et al. N Engl J Med 2010; 362:886-895 DOI: 10.1056/NEJMoa0907272. link: https://www.nejm.org/doi/full/10.1056/NEJMoa0907272